Aging Reversal Genetics

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  • Add free, open Aging Reversal Genetics' courses below.

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Add free, open Aging Reversal Genetics' courses Web Site Organization (if any) Degree / Non-degree Instructor's Name URL Other Info Language Tags
The Biology of Aging: Age-Related Diseases and Interventions https://dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/index.htm MIT OCW non-degree Dr. Dudley W. Lamming, Dr. Eric L. Bell Browser Start anytime English Undergraduate
Genetics - "This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans." https://ocw.mit.edu/courses/7-03-genetics-fall-2004/ MIT OCW non-degree Prof. Chris Kaiser, Prof. Gerald Fink, Prof. Leona Samson, Dr. Michelle Mischke Browser Start anytime English Undergraduate


Genomics And Computational Biology https://ocw.mit.edu/courses/hst-508-genomics-and-computational-biology-fall-2002/pages/study-materials/ MIT OCW non-degree Dr. George Church Browser Start anytime English Graduate, Undergraduate


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Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. Transcriptomic reprogramming for neuronal age reversal, Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1.

Abstract Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as neurodegenerative diseases are leading causes of death worldwide, and they are becoming a pressing problem for our society. To address this global challenge, there is a need for novel, safe, and effective rejuvenation therapies aimed at reversing age-related phenotypes and improving human health. With gene expression being a key determinant of cell identity and function, and in light of recent studies reporting rejuvenation effects through genetic perturbations, we propose an age reversal strategy focused on reprogramming the cell transcriptome to a youthful state. To this end, we suggest using transcriptomic data from primary human cells to predict rejuvenation targets and develop high-throughput aging assays, which can be used in large perturbation screens. We propose neural cells as particularly relevant targets for rejuvenation due to substantial impact of neurodegeneration on human frailty. Of all cell types in the brain, we argue that glutamatergic neurons, neuronal stem cells, and oligodendrocytes represent the most impactful and tractable targets. Lastly, we provide experimental designs for anti-aging reprogramming screens that will likely enable the development of neuronal age reversal therapies, which hold promise for dramatically improving human health.

The problem of aging Aging is a major risk factor for multiple prevalent human diseases including cancer, cardiovascular disease, neurodegeneration, diabetes, and most recently COVID-19 (Fig. 1) (Xu et al. 2021; National Center for Health Statistics 2022). The mortality rate associated with all these diseases increases exponentially with age. Although deaths are the most apparent outcome of age-related diseases, the associated suffering and drop in quality of life also have a significant negative impact on our society (Netuveli et al. 2006). This is especially evident in the elderly suffering from dementia and neurodegenerative movement disorders, which reduce personal autonomy and independence and have no available cure.

Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. Transcriptomic reprogramming for neuronal age reversal, Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1.


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DSpace@MIT. 2023. Transcriptomic reprogramming for neuronal age reversal. Cambridge, MA: ttps://dspace.mit.edu/bitstream/handle/1721.1/150336/439_2023_Article_2529.pdf?sequence=1&isAllowed=y.

Dutchen, Stephanie. 2023. Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse It: Study in mice implicates changes to way DNA is organized, regulated rather than changes to genetic code itself. January 12. Cambridge, MA: hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse .

Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. Transcriptomic reprogramming for neuronal age reversal, Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1.

Yang, Jae-Hyun, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair . 2023. NEW STUDY: Discovery of Chemical Means to Reverse Aging and Restore Cellular Function: On July 12, 2023, a new priority research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”. BUFFALO, NY: www.aging-us.com/news-room/NEW-STUDY-Discovery-of-Chemical-Means-to-Reverse-Aging-and-Restore-Cellular-Function.


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The Biology of Aging: Age-Related Diseases and Interventions » Syllabus The Biology of Aging: Age-Related Diseases and Interventions » Syllabus. Cambridge, MA: dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm.

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DSpace@MIT. 2011. Syllabus | The Biology of Aging - DSpace@MIT. Cambridge, MA: dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm.



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MacLeod, Scott GK. 2024.

How best @GeoChurch to interoperate "#AlphaFold3 predicts ..." https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/#future-cell-biology + your great #MITOCW course https://ocw.mit.edu/courses/hst-508-genomics-and-computational-biology-fall-2002/ added to 4 #WUaSsubjects https://wiki.worlduniversityandschool. org/wiki/Aging_Reversal_Genetics in #RealisticVirtualEarthForAgingReversal?

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MacLeod, Scott. GK. 2024.

INCREDIBLE: a new course on "#GenomicsAndComputationalBiology" (searched on "courses on #AgingReversalGenetics #MITOCW -centric wiki @WorldUnivAndSch @GeoChurch") -https://ocw.mit.edu/courses/hst-508-genomics-and-computational-biology-fall-2002/ Adding: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics #WUaSUnivs How to dev in #RealisticVirtualEarthForGenomics ? ...

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Macleod, Scott GK. 2023.

NEW /Aging_Reversal_Genetics' wiki school: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics @WorldUnivAndSch; See The "Longevity" wiki school too: https://wiki.worlduniversityandschool.org/wiki/Longevity See also the #MITOCW resources, & MORE~Add further resources #AvatarAgentElectronicHealthRecords >#RealisticVirtualEarthForGenetics ~

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retweeting We have a great lineup of speakers for Longevity Global's Summit this year Buck Institute for Research on Aging Dec. 5th and 6th:Register Here: https://lnkd.in/gWnVxNQz https://twitter.com/LongevityGL/status/1724643507338654120 


AND Longevity wiki school pic -  NEW /Aging_Reversal_Genetics' wiki school: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics @WorldUnivAndSch; See The "Longevity" wiki school too: https://wiki.worlduniversityandschool.org/wiki/Longevity See also the #MITOCW resources, & MORE~Add further resources #AvatarAgentElectronicHealthRecords >#RealisticVirtualEarthForGenetics ?

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Church, George, with Rhonda Patrick (interviewer). 2022. George Church, PhD: Rewriting Genomes to Eradicate Disease and Aging. Cambridge, MA: FoundMyFitness.

Church, George, with Scott Pelley (interviewer). 2019. How soon could humans reverse the aging process with genetic engineering?. December 6. New York, NY: 60 Minutes.


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OpenSim. 2012. http://opensimulator.org/wiki/Main_Page (http://www.scribd.com/doc/57959626/OpenSimulator-School-Quick-Start-Guide)

Open Croquet. 2012. http://c2.com/cgi/wiki?OpenCroquet and http://www.opencroquet.org/

Open Wonderland. 2012. http://openwonderland.org/

Primary Games. 2013. http://www.primarygames.com/arcade/virtualworlds.php

Quest Atlantis. 2012. http://atlantisremixed.org/ (http://www.youtube.com/watch?v=SZoT3pilNPI).

Second Life - Harvard's virtual island. 2012. http://slurl.com/secondlife/Berkman/115/53/25 - and teach, learn and share ideas - in group voice chat, or in group type chat, and via building.

SmallWorlds. 2014. https://www.smallworlds.com/

There.com. 2014. http://www.there.com/

Twinity. 2014. http://www.twinity.com/en/choose-your-free-avatar

Unity3D. 2012. http://unity3d.com/

WiloStar3D. 2013. https://www.wilostar3d.com/

World of Warcraft in School. 2014. http://wowinschool.pbworks.com/w/page/5268731/FrontPage


Add a learning-oriented virtual world here:

Travel to this virtual island to learn building:


Item Number[edit]

Global ID and Multiple IDs - see https://www.mediawiki.org/wiki/Requests_for_comment/New_sites_system

Bar code


Labels[edit]

Learning Networking[edit]

Teach and Learn using free Social Networking software to share what courses, etc., you find edifying, what you enjoy learning ....


About Me - World University and School - http://about.me


Academia.edu's World University and School - http://worlduniversityandschool.academia.edu/

Facebook.com's World University and School - http://www.facebook.com/group.php?gid=48753608141 ('This group may be archived').


Good Reads - http://www.goodreads.com/group/show/99021-worlduniversityandschool


Google + Profiles - [email protected] - Scott MacLeod - https://plus.google.com/115890623333932577910/


Google + Profiles Company page - [email protected] - World University and School - https://plus.google.com/u/0/b/108179352492243955816/108179352492243955816/posts


Google Groups' World University and School - http://groups.google.com/group/World-University-and-School


Like


LinkedIn's World University and School - http://www.linkedin.com/groups/World-University-School-4024337


Quora - http://www.quora.com/


Research Gate - http://www.researchgate.net/


Redditt.com's World University and School - http://www.reddit.com/user/WorldUnivandSch/


Tribe.net's World University and School - http://tribes.tribe.net/worlduniversityandschool


Twitter.com's World University and School - http://twitter.com/WorldUnivandSch


Wer Kennt Wen - World University and School - http://www.wer-kennt-wen.de/


World University & School 'subject page' group


World University & School Share This


Yahoo Groups' World University and School: http://groups.yahoo.com/group/worlduniversityandschool/


Linked Open Data[edit]

Linked Open Data, Linked Data for artificial intelligence and machine learning, with a focus on privacy and security.


List of Wikipedias[edit]

List of Wikipedias. 2015. List of Wikipedias. meta.wikimedia.org/wiki/List_of_Wikipedias .


RSS Feed[edit]

Save this page for download in the following formats[edit]

atom

GeoJSON

csv.csvm

map.html

csv

xls

rdf

klm


TV-Live Broadcasting[edit]

Broadcast to television


Teach and learn using free TV-Live Broadcasting software to the web:


Google Meets - https://meet.google.com


Justin TV - http://www.justin.tv


Livestream TV - http://www.livestream.com


UnHangouts - https://unhangout.media.mit.edu/


Ustream TV - http://ustream.tv


Video Communication[edit]

Teach and learn using free TV-Live Broadcasting software


Free video conferencing

iChat - http://www.apple.com/macosx/what-is-macosx/ichat.html


Skype - http://www.skype.com/


Free, group video conferencing

AnyMeeting - http://anymeeting.com/homepage/

Google Meet - https://meet.google.com

Meeting Burner - http://www.meetingburner.com/index?page=signup-v2 – up to 15 connection

ooVoo - http://www.oovoo.com/home.aspx

Paltalk - http://www.paltalk.com

sifonr - free communication - http://www.sifonr.com/‎

Tokbox | OpenTok - API - http://tokbox.com/opentok

Vyew - http://vyew.com/

Web Huddle - https://www.webhuddle.com/homepage.jsp - http://sourceforge.net/projects/webhuddle/

Zoom.us - Cloud HD Video Meetings - http://zoom.us/


Universal Translator at WUaS[edit]

https://wiki.worlduniversityandschool.org/wiki/WUaS_Universal_Translator

Google Translate language:

Sugar Labs: Translation System language:

Region:


Select Translators

Babelxl. 2015. Babelxl: the best translator. http://babelxl.com/ .

Babylon Online Translation. 2015. Babylon Online Translation. (Offering hundreds of dictionaries and translation in more than 800 language pairs). translation.babylon.com/ .

Free-translator.com. 2015. Free-translator.com. free-translator.com/ .

Google Translate. 2015. Google Translate. translate.google.com/ .

SDL Free Translation. 2015. SDL Free Translation. freetranslation.com/ .

Word Lingo Free Translation Tools. 2015. Word Lingo Free Translation Tools and Machine Translation Products. worldlingo.com/en/products/ .


Select Video with Subtitles for Translation

Amara.org. 2015. Amara.org: Captions, subtitles, and translations simplified. (Amara makes video globally accessible: Captions, subtitles, and translations simplified). amara.org/en/

TED Open Translation Project. 2015. TED Open Translation Project. (See - https://www.ted.com/about/programs-initiatives/ted-open-translation-project - and - https://www.ted.com/participate/translate/get-started). ted.com/about/programs-initiatives/ted-open-translation-project .


The "Universitian" Newspaper at World University and School[edit]

The "Universitian" Newspaper at WUaS


Wiki Software for Courses[edit]

Media Wiki - http://www.mediawiki.org/wiki/MediaWiki


PB Works - http://pbworks.com/


Wet Paint - http://wikisineducation.wikifoundry.com/


Wikia - http://www.wikia.com/Wikia


Wikispaces - http://www.wikispaces.com/


Wikidata / Bots[edit]

http://meta.wikimedia.org/wiki/Wikidata/Bots


World University and School Accreditation[edit]

World University and School Licensing[edit]

World University and School - like Wikipedia with Greatest Universities' OpenCourseWare - incorporated as a nonprofit effective April 2010 and is a 501(c)(3) tax-exempt, educational organization charity.

World University & School is a community of learners and teachers who value — and are themselves strengthened by — the rich diversity of its participants. In order to cultivate a flourishing teaching, learning and creating conversation in a diverse and complex world, WUaS welcomes all languages, students, families, faculty, board members, and staff with differences based on (but not limited to) race, color, ethnicity, religion, age, gender, sexual orientation, family structure, and economic background.

All content on this site is freely available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) - http://creativecommons.org/licenses/by-nc-sa/4.0/ .



World University and School Main Areas[edit]


WUaS: https://wiki.worlduniversityandschool.org/wiki/World_University
Admissions' Department: https://wiki.worlduniversityandschool.org/wiki/Admissions_at_World_University_and_School
Courses: https://wiki.worlduniversityandschool.org/wiki/Courses
Subjects: https://wiki.worlduniversityandschool.org/wiki/Subjects
Languages: https://wiki.worlduniversityandschool.org/wiki/Languages
Library Resources: https://wiki.worlduniversityandschool.org/wiki/Library_Resources
Nation States: https://wiki.worlduniversityandschool.org/wiki/Nation_States
You at World University: https://wiki.worlduniversityandschool.org/wiki/You_at_World_University
Educational Software: https://wiki.worlduniversityandschool.org/wiki/Educational_Software
Museums: https://wiki.worlduniversityandschool.org/wiki/Museums
Research: https://wiki.worlduniversityandschool.org/wiki/Research
Hardware Resource Possibilities: https://wiki.worlduniversityandschool.org/wiki/Hardware_Resource_Possibilities
Frequently Asked Questions at World University & School: https://wiki.worlduniversityandschool.org/wiki/Frequently_Asked_Questions
World University Foundation: https://wiki.worlduniversityandschool.org/wiki/World_University_Foundation


Templates at World University and School[edit]


LANGUAGE TEMPLATE: https://wiki.worlduniversityandschool.org/wiki/LANGUAGE_TEMPLATE
LIBRARY TEMPLATE: https://wiki.worlduniversityandschool.org/wiki/LIBRARY_TEMPLATE
MUSEUM TEMPLATE: https://wiki.worlduniversityandschool.org/wiki/MUSEUM_TEMPLATE
NATION STATE TEMPLATE: https://wiki.worlduniversityandschool.org/wiki/NATION_STATE_TEMPLATE
SUBJECT TEMPLATE: https://wiki.worlduniversityandschool.org/wiki/SUBJECT_TEMPLATE


Volunteers at World University and School: https://wiki.worlduniversityandschool.org/wiki/Volunteers


Home: https://wiki.worlduniversityandschool.org/wiki/World_University
For questions, or help editing a page, email: [email protected]

WUaS's Guidestar.org listing - https://www.guidestar.org/organizations/27-3105368/world-university-school.aspx .


Please donate through PayPal to tax-exempt - 501 (c) (3) - World University and School at
http://worlduniversityandschool.org
Thank you!