Aging Reversal Genetics: Difference between revisions

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Scott WUaS

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Line 126: ===Ideas=== Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. [https://link.springer.com/article/10.1007/s00439-023-02529-1 Transcriptomic reprogramming for neuronal age reversal], Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1. Abstract Aging is a progressive multifaceted functional decline of a biological system. Chronic age-related conditions such as neurodegenerative diseases are leading causes of death worldwide, and they are becoming a pressing problem for our society. To address this global challenge, there is a need for novel, safe, and effective rejuvenation therapies aimed at reversing age-related phenotypes and improving human health. With gene expression being a key determinant of cell identity and function, and in light of recent studies reporting rejuvenation effects through genetic perturbations, we propose an age reversal strategy focused on reprogramming the cell transcriptome to a youthful state. To this end, we suggest using transcriptomic data from primary human cells to predict rejuvenation targets and develop high-throughput aging assays, which can be used in large perturbation screens. We propose neural cells as particularly relevant targets for rejuvenation due to substantial impact of neurodegeneration on human frailty. Of all cell types in the brain, we argue that glutamatergic neurons, neuronal stem cells, and oligodendrocytes represent the most impactful and tractable targets. Lastly, we provide experimental designs for anti-aging reprogramming screens that will likely enable the development of neuronal age reversal therapies, which hold promise for dramatically improving human health. The problem of aging Aging is a major risk factor for multiple prevalent human diseases including cancer, cardiovascular disease, neurodegeneration, diabetes, and most recently COVID-19 (Fig. 1) (Xu et al. 2021; National Center for Health Statistics 2022). The mortality rate associated with all these diseases increases exponentially with age. Although deaths are the most apparent outcome of age-related diseases, the associated suffering and drop in quality of life also have a significant negative impact on our society (Netuveli et al. 2006). This is especially evident in the elderly suffering from dementia and neurodegenerative movement disorders, which reduce personal autonomy and independence and have no available cure. Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. [https://link.springer.com/article/10.1007/s00439-023-02529-1 Transcriptomic reprogramming for neuronal age reversal], Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1. Line 318 ⟶ 329: ===Select References=== DSpace@MIT. 2023. [https://dspace.mit.edu/bitstream/handle/1721.1/150336/439_2023_Article_2529.pdf?sequence=1&isAllowed=y Transcriptomic reprogramming for neuronal age reversal]. Cambridge, MA: ttps://dspace.mit.edu/bitstream/handle/1721.1/150336/439_2023_Article_2529.pdf?sequence=1&isAllowed=y. Dutchen, Stephanie. 2023. [https://hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse It: Study in mice implicates changes to way DNA is organized, regulated rather than changes to genetic code itself]. January 12. Cambridge, MA: hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse . Plesa, Alexandru M., Michael Shadpour, Ed Boyden & George M. Church. 2023. [https://link.springer.com/article/10.1007/s00439-023-02529-1 Transcriptomic reprogramming for neuronal age reversal], Heidelberg, Germany: link.springer.com/article/10.1007/s00439-023-02529-1. Yang, Jae-Hyun, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair . 2023. [https://www.aging-us.com/news-room/NEW-STUDY-Discovery-of-Chemical-Means-to-Reverse-Aging-and-Restore-Cellular-Function#:~:text=The%20Harvard%20researchers%20previously%20demonstrated,specific%20Yamanaka%20genes%20into%20cells NEW STUDY: Discovery of Chemical Means to Reverse Aging and Restore Cellular Function: On July 12, 2023, a new priority research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”]. BUFFALO, NY: www.aging-us.com/news-room/NEW-STUDY-Discovery-of-Chemical-Means-to-Reverse-Aging-and-Restore-Cellular-Function. Line 363 ⟶ 378: The Biology of Aging: Age-Related Diseases and Interventions » Syllabus [https://dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm The Biology of Aging: Age-Related Diseases and Interventions » Syllabus]. Cambridge, MA: dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm. similar: DSpace@MIT. 2011. [https://dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm Syllabus \| The Biology of Aging - DSpace@MIT]. Cambridge, MA: dspace.mit.edu/bitstream/handle/1721.1/148350/7-342-fall-2011/contents/syllabus/index.htm. Line 393 ⟶ 414: ===Select Twitters=== Macleod, Scott GK. 2023. NEW /Aging_Reversal_Genetics' wiki school: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics @WorldUnivAndSch; See The "Longevity" wiki school too: https://wiki.worlduniversityandschool.org/wiki/Longevity See also the #MITOCW resources, & MORE~Add further resources #AvatarAgentElectronicHealthRecords >#RealisticVirtualEarthForGenetics ~ https://twitter.com/WorldUnivAndSch/status/1726262062626845141 https://twitter.com/sgkmacleod/status/1726264219417317553?t=W30Gte-rwKtYs8SIq9FEKw&s=19 https://twitter.com/scottmacleod/status/1726263782358524053?t=IgSws1UbIWoYZoqvjdIQRw&s=19 https://twitter.com/WUaSPress/status/1726263890785513611?t=vcRZwMH31mFTZfUQmMpHqQ&s=19 https://twitter.com/TheOpenBand/status/1726264116799844414?t=VALQ6wG804fWUvE6ePCJNQ&s=19 https://twitter.com/HarbinBook/status/1726263993604649186?t=5Uafk4PMyrjusq1xDrgzgw&s=19 retweeting We have a great lineup of speakers for Longevity Global's Summit this year Buck Institute for Research on Aging Dec. 5th and 6th:Register Here: https://lnkd.in/gWnVxNQz https://twitter.com/LongevityGL/status/1724643507338654120 AND Longevity wiki school pic - NEW /Aging_Reversal_Genetics' wiki school: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics @WorldUnivAndSch; See The "Longevity" wiki school too: https://wiki.worlduniversityandschool.org/wiki/Longevity See also the #MITOCW resources, & MORE~Add further resources #AvatarAgentElectronicHealthRecords >#RealisticVirtualEarthForGenetics ? https://twitter.com/WorldUnivAndSch/status/1726261267327828267 Pittsburgh, PA: twitter.com/WorldUnivAndSch/status/1726261267327828267. Line 467 ⟶ 522: ===World University and School Links=== Aging Reversal Genetics: https://wiki.worlduniversityandschool.org/wiki/Aging_Reversal_Genetics Animal Behavior: https://wiki.worlduniversityandschool.org/wiki/Animal_Behavior Animal Studies: https://wiki.worlduniversityandschool.org/wiki/Animal_Studies Athletics, Physical Education and Recreation: https://wiki.worlduniversityandschool.org/wiki/Athletics,_Physical_Education_and_Recreation Biochemistry: https://wiki.worlduniversityandschool.org/wiki/Biochemistry Biological Anthropology: https://wiki.worlduniversityandschool.org/wiki/Biological_Anthropology Biological Engineering: https://wiki.worlduniversityandschool.org/wiki/Biological_Engineering Biology: https://wiki.worlduniversityandschool.org/wiki/Biology Biomedical Engineering: https://wiki.worlduniversityandschool.org/wiki/Biomedical_Engineering Bonobo chimpanzee: https://wiki.worlduniversityandschool.org/wiki/Bonobo_chimpanzee Botany: https://wiki.worlduniversityandschool.org/wiki/Botany Brain and Cognitive Sciences: https://wiki.worlduniversityandschool.org/wiki/Brain_and_Cognitive_Sciences Cancer Biology: https://wiki.worlduniversityandschool.org/wiki/Cancer_Biology Chemistry: https://wiki.worlduniversityandschool.org/wiki/Chemistry Chips - 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